A physiologically-based pharmacokinetic model of docetaxel in SCID mice bearing SKOV3 human ovarian xenografts
- J. A. Florian, W. C. Zamboni, +6 authors R. S. Parker
- AACR Annual Meeting,
Introduction: Cancer is a collection of diseases resulting from a series of genetic mutations and is characterized by an imbalance between proliferation and cell apoptosis. Common modalities for treating cancer include surgical excision of the tumor mass, local exposure to radiation, or systemic administration of a chemotherapeutic agent. Whenever possible, the tumor mass will be removed, but the surgeon cannot be certain that all cancerous cells were excised, particularly if the cancerous mass has already become invasive. Also, by the time of initial tumor mass detection, undetectable metastases may have already spread to other remote body locations, motivating the use of a more systemic treatment. The scheduling of chemotherapeutic treatments, while extensively studied in an empirical fashion, has not been the subject of mathematical evaluation from an optimal scheduling standpoint in the clinical setting. The latter point is especially relevant given that chemotherapeutics also harm healthy proliferating cells, reducing patient quality of life and limiting treatment effectiveness.