Influence of Th1/Th2 Cytokines and Nitric Oxide in Murine Systemic Infection Induced by Sporothrix schenckii

@article{Maia2005InfluenceOT,
  title={Influence of Th1/Th2 Cytokines and Nitric Oxide in Murine Systemic Infection Induced by Sporothrix schenckii},
  author={Danielle Cardoso Geraldo Maia and Micheli Fernanda Sass{\'a} and Marisa Campos Pol{\'e}si Placeres and Iracilda Zeppone Carlos},
  journal={Mycopathologia},
  year={2005},
  volume={161},
  pages={11-19}
}
In an attempt to elucidate the effects of Sporothrix schenckii infection on the immune response, our laboratory has developed a murine model of disseminated sporotrichosis. Helper T cells can be further subdivided into Th1 and Th2 phenotypes. The differentiation of two subsets of T lymphocytes is driven by IL-12 and IL-4 cytokines, respectively. Th1 cells produce IFN-γ that activate macrophages and promote cell-mediated immunity. In addition, we found low levels of iNOS and NO production in the… CONTINUE READING