Influence of TAT-peptide polymerization on properties and transfection activity of TAT/DNA polyplexes.

@article{Manickam2005InfluenceOT,
  title={Influence of TAT-peptide polymerization on properties and transfection activity of TAT/DNA polyplexes.},
  author={Devika Soundara Manickam and Harender S Bisht and Lei Wan and Guangzhao Mao and David Oupick{\'y}},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2005},
  volume={102 1},
  pages={293-306}
}
Use of bioactive cationic peptides as gene carriers is limited by instability of their DNA complexes in vivo and by the loss of their biological activity due to undesired interactions of their bioactive parts with the DNA. To overcome the two major limitations, biodegradable high-molecular-weight form of TAT peptide (POLYTAT) sensitive to cellular redox-potential gradients was synthesized in this study by oxidative polycondensation. Physicochemical and transfection properties of DNA polyplexes… CONTINUE READING
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