Influence of Surface Chemistry on Ibuprofen Adsorption and Confinement in Mesoporous Silicon Microparticles.

@article{Mkil2016InfluenceOS,
  title={Influence of Surface Chemistry on Ibuprofen Adsorption and Confinement in Mesoporous Silicon Microparticles.},
  author={Ermei M M{\"a}kil{\"a} and Henri Kivel{\"a} and Neha Shrestha and Alexandra M R Correia and Martti Kaasalainen and Edwin Kukk and Jouni Hirvonen and H{\'e}lder A Santos and Jarno J Salonen},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  year={2016},
  volume={32 49},
  pages={
          13020-13029
        }
}
The effect of adsorption and confinement on ibuprofen was studied by immersion loading the molecules into porous silicon (PSi) microparticles. The PSi microparticles were modified into thermally oxidized PSi (TOPSi) and thermally hydrocarbonized PSi (THCPSi) to evaluate the effects of the loading solvent and the surface chemistry on the obtainable drug payloads. The payloads, location, and the molecular state of the adsorbed drug were evaluated using thermal analysis. The results showed that… CONTINUE READING