Influence of Substituent Chain Branching on the Transfection Efficacy of Cyclopropenium-Based Polymers

@inproceedings{Brucks2017InfluenceOS,
  title={Influence of Substituent Chain Branching on the Transfection Efficacy of Cyclopropenium-Based Polymers},
  author={Spencer D. Brucks and Jessica Leigh Freyer and Tristan H Lambert and Lu{\'i}s Miguel Campos},
  booktitle={Polymers},
  year={2017}
}
The realization of gene therapy relies on the development of delivery vectors with high efficiency and biocompatibility. With a multitude of structures accessible, the core challenge is precisely tuning vector structure to probe and optimize structure⁻property relationships. Employing a modular strategy, two pairs of cationic polymers based on the trisaminocyclopropenium (TAC) ion were synthesized where the substituents differ in the degree of alkyl chain branching. All TAC-based polymers… CONTINUE READING

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