Influence of Substituent Chain Branching on the Transfection Efficacy of Cyclopropenium-Based Polymers

  title={Influence of Substituent Chain Branching on the Transfection Efficacy of Cyclopropenium-Based Polymers},
  author={Spencer D. Brucks and Jessica L. Freyer and Tristan H. Lambert and Luis M. Campos},
The realization of gene therapy relies on the development of delivery vectors with high efficiency and biocompatibility. With a multitude of structures accessible, the core challenge is precisely tuning vector structure to probe and optimize structure–property relationships. Employing a modular strategy, two pairs of cationic polymers based on the trisaminocyclopropenium (TAC) ion were synthesized where the substituents differ in the degree of alkyl chain branching. All TAC-based polymers… 

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