Influence of SigB inactivation on Corynebacterium glutamicum protein secretion

@article{Watanabe2012InfluenceOS,
  title={Influence of SigB inactivation on Corynebacterium glutamicum protein secretion},
  author={Keiro Watanabe and Hiroshi Teramoto and N Suzuki and Masayuki Inui and Hideaki Yukawa},
  journal={Applied Microbiology and Biotechnology},
  year={2012},
  volume={97},
  pages={4917-4926}
}
The non-essential Corynebacterium glutamicum sigma factor, sigB, modulates global gene expression during the transition from exponential growth to the stationary phase. Utilizing a signal peptide derived from C. glutamicum R CgR_0949, a sigB disruption mutant able to secrete 3- to 5-fold more green fluorescence protein (GFP) and α-amylase than the wild type strain was isolated. The signal peptide selectively enabled the mutant to produce greater amounts of both proteins, which were in turn… CONTINUE READING
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