Corpus ID: 79076424

Influence of Sex and CRF Pathways as Determinants in 5-HT Sensitivity Abbreviated title: Sex and Stress in 5-HT Sensitivity

@inproceedings{McEuen2009InfluenceOS,
  title={Influence of Sex and CRF Pathways as Determinants in 5-HT Sensitivity Abbreviated title: Sex and Stress in 5-HT Sensitivity},
  author={Jonathan Gabriel McEuen and Katharine Semsar and Maria A. Lim and Tracy L. Bale},
  year={2009}
}
250) Stress sensitivity and sex are predictive factors in affective disorder susceptibility. Serotonin (5HT) pathway recruitment by corticotropin-releasing factor (CRF) during stress is necessary in adaptive coping behaviors, but sex differences in such responses have not been investigated. Utilizing SSRI administration to acutely elevate 5-HT in a genetic model of stress sensitivity, we examined behavioral and physiological responses in male and female stress-sensitive CRF receptor-2 deficient… Expand
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TLDR
Data suggest that multiple sites related to 5-HTergic stimulation, corticosterone production, and negative feedback of HPA neurocircuitry combine to produce higher female stress responsiveness, supporting a potential for sex-specific involvement of 5- HT and stress pathways in the etiology of affective disorders. Expand
The effects of repeated restraint stress on energy balance and behavior of mice with selective deletion of CRF receptors
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The results suggest thatCRFR1 are required for stress-induced weight loss, but that hyper-reactivity of the HPA axis in RRS mice exposed to a subsequent novel stress is independent of CRFR1. Expand

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