Corpus ID: 79076424

Influence of Sex and CRF Pathways as Determinants in 5-HT Sensitivity Abbreviated title: Sex and Stress in 5-HT Sensitivity

  title={Influence of Sex and CRF Pathways as Determinants in 5-HT Sensitivity Abbreviated title: Sex and Stress in 5-HT Sensitivity},
  author={Jonathan Gabriel McEuen and Katharine Semsar and Maria A. Lim and Tracy L. Bale},
250) Stress sensitivity and sex are predictive factors in affective disorder susceptibility. Serotonin (5HT) pathway recruitment by corticotropin-releasing factor (CRF) during stress is necessary in adaptive coping behaviors, but sex differences in such responses have not been investigated. Utilizing SSRI administration to acutely elevate 5-HT in a genetic model of stress sensitivity, we examined behavioral and physiological responses in male and female stress-sensitive CRF receptor-2 deficient… Expand
Sex differences in the serotonergic influence on the hypothalamic-pituitary-adrenal stress axis.
Data suggest that multiple sites related to 5-HTergic stimulation, corticosterone production, and negative feedback of HPA neurocircuitry combine to produce higher female stress responsiveness, supporting a potential for sex-specific involvement of 5- HT and stress pathways in the etiology of affective disorders. Expand
The effects of repeated restraint stress on energy balance and behavior of mice with selective deletion of CRF receptors
The results suggest thatCRFR1 are required for stress-induced weight loss, but that hyper-reactivity of the HPA axis in RRS mice exposed to a subsequent novel stress is independent of CRFR1. Expand


Increased Depression-Like Behaviors in Corticotropin-Releasing Factor Receptor-2-Deficient Mice: Sexually Dichotomous Responses
The results may reveal an interaction of CRF pathways with other known antidepressant systems and may also support an involvement ofCRF receptors in the development of depression such that elevated CRFR1 activity, in the absence of CRFR2, increases depression-like behaviors. Expand
Failure to Mount Adaptive Responses to Stress Results in Dysregulation and Cell Death in the Midbrain Raphe
A requirement for homeostatic maintenance in response to stress in the raphe, where dysregulation may be a critical predictor of affective disorder onset, is supported. Expand
Stress sensitivity and the development of affective disorders
  • T. Bale
  • Medicine, Psychology
  • Hormones and Behavior
  • 2006
Examination of sex differences in CRF and downstream targets may aid in the elucidation of the underlying causes of the increased disease presentation in females. Expand
Differential Effects of Acute and Chronic Social Defeat Stress on Hypothalamic‐Pituitary‐Adrenal Axis Function and Hippocampal Serotonin Release in Mice
It is demonstrated that social defeat induces prolonged activation of the HPA axis and alterations in 5‐HT neurotransmission that could be of relevance to some of the pathological abnormalities observed in clinical depression. Expand
Role of stress, corticotrophin releasing factor (CRF) and amygdala plasticity in chronic anxiety
The hypotheses that stress induced plasticity within the amygdala may be a critical step in the pathophysiology of the development of chronic anxiety states are summarized. Expand
Differential actions of acute and chronic citalopram on the rodent hypothalamic-pituitary-adrenal axis response to acute restraint stress.
Both acute and chronic citalopram treatment has the potential to alter the rodent response to acute restraint stress and effects appear to be regulated by the AVP-containing subset of CRF neurons in the pPVN and thus suggest that parvocellular AVP may have an important role in mediating the actions of SSRIs. Expand
Regulation of 5‐HT Receptors and the Hypothalamic‐Pituitary‐Adrenal Axis
Animal studies point to the possibility that many of the 5‐HT receptor changes observed in suicide brains may be a result of, or may be worsened by, the HPA overactivity that may be present in some suicide victims. Expand
Lasting anxiogenic effects of feline predator stress in mice: Sex differences in vulnerability to stress and predicting severity of anxiogenic response from the stress experience
Severity of effects of predator stress on anxiety-like behaviors in EPM and startle were well predicted by measures of cat behavior and probability of mouse defensive response to particular cat behaviors during the cat exposure. Expand
Forced swim stress activates rat hippocampal serotonergic neurotransmission involving a corticotropin‐releasing hormone receptor‐dependent mechanism
The data suggest that the raphe‐hippocampal serotonin system is able to mount, CRH receptor‐dependent, responses to specific stressful situations that surpass the usually observed maximal increases of about 300% of baseline during stress and enhanced vigilance. Expand
Estrogen, serotonin, and mood disturbance: where is the therapeutic bridge?
A model is proposed in which differential sensitivity to mood disorders explains the differential response by some women to periods of normal hormonal changes. Expand