Influence of Sequence and Covalent Modifications on Yeast tRNA Dynamics

of Sequence and Covalent Modifications on
Yeast tRNA Dynamics},
  author={Xiaoju Zhang and Ross C. Walker and Eric M Phizicky and David H. Mathews},
  booktitle={Journal of chemical theory and computation},
Modified nucleotides are prevalent in tRNA. Experimental studies reveal that these covalent modifications play an important role in tuning tRNA function. In this study, molecular dynamics (MD) simulations were used to investigate how modifications alter tRNA dynamics. The X-ray crystal structures of tRNA(Asp), tRNA(Phe), and tRNA(iMet), both with and without modifications, were used as initial structures for 333 ns explicit solvent MD simulations with AMBER. For each tRNA molecule, three… CONTINUE READING
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