Influence of Selective Inhibition of Monoamine Oxidase A or B on Striatal Metabolism of l‐DOPA in Hemiparkinsonian Rats

@article{Finberg1995InfluenceOS,
  title={Influence of Selective Inhibition of Monoamine Oxidase A or B on Striatal Metabolism of l‐DOPA in Hemiparkinsonian Rats},
  author={John P.M. Finberg and J. Wang and David S. Goldstein and Irwin J. Kopin and K. S. Bankiewicz},
  journal={Journal of Neurochemistry},
  year={1995},
  volume={65}
}
Abstract: The effect of selective inhibition of monoamine oxidase (MAO) subtypes A and B on striatal metabolism of DOPA to dopamine (DA), 3,4‐dihydroxyphenylacetic acid (DOPAC), and 4‐hydroxy‐3‐methoxyphenylacetic acid (homovanillic acid; HVA) was studied in halothane‐anesthetized rats 3 weeks after unilateral 6‐hydroxydopamine lesion of the substantia nigra. Implantation of bilateral microdialysis probes allowed simultaneous quantitation of metabolite production on lesioned and control sides… 
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54 Citations
Highly Influential Citations
2
Background Citations
17
Methods Citations
2
Results Citations
4

54 Citations

Effect of Long‐Term Treatment with Selective Monoamine Oxidase A and B Inhibitors on Dopamine Release from Rat Striatum In Vivo
TLDR
DA metabolism was reduced only by clorgyline, whereas neuronal release of DA was enhanced by both MAO‐A andMAO‐B inhibitors on chronic administration, and the enhanced DA release does not appear to be dependent on production of amphetamine‐like metabolites of the inhibitor.
Increased L‐DOPA‐derived dopamine following selective MAO‐A or ‐B inhibition in rat striatum depleted of dopaminergic and serotonergic innervation
TLDR
This work sought to clarify the roles of MAO‐A andMAO‐B in deamination of DA formed from exogenous L‐DOPA in rat striatum depleted of dopaminergic, or both dopamine and serotonergic innervations.
Microdialysis study of the effects of the antiparkinsonian drug budipine on L‐DOPA‐induced release of dopamine and 5‐hydroxytryptamine by rat substantia nigra and corpus striatum
TLDR
It is concluded that budipine, at a therapeutically relevant dose, potentiates the release of dopamine newly synthesised from L‐DOPA from either end of the nigrostriatal dopamine axis.
Biochemical effects of the monoamine neurotoxins DSP‐4 and MDMA in specific brain regions of MAO‐B‐deficient mice
TLDR
The present findings suggest that MAO‐B is not involved in the mechanism of action of DSP‐4, whereas it plays opposite roles in MDMA‐induced DA and 5HT depletions.
Striatal Dopamine Metabolism in Monoamine Oxidase B‐Deficient Mice : A Brain Dialysis Study
TLDR
It is suggested that in mice, DA is only metabolized byMAO A under basal conditions and by both MAO A and B at high concentrations, in contrast to the rat, where DA is always metabolizing by MAO B regardless of concentration.
Selective inhibition of monoamine oxidase A or B reduces striatal oxidative stress in rats with partial depletion of the nigro-striatal dopaminergic pathway
Effects of Catechol-O-methyltransferase Inhibition on the Rates of Uptake and Reversibility of 6-Fluoro-l-Dopa Trapping in MPTP-induced Parkinsonism in Monkeys
Increased striatal dopamine production from L-DOPA following selective inhibition of monoamine oxidase B by R(+)-N-propargyl-1-aminoindan (rasagiline) in the monkey.
Striatal extracellular fluid concentrations of dopamine and metabolites in response to direct striatal administration of two L-DOPA boluses administered sequentially were determined in three rhesus…
The novel type B MAO inhibitor PF9601N enhances the duration of L-DOPA-induced contralateral turning in 6-hydroxydopamine lesioned rats
TLDR
The results suggest that PF9601N may be used as a novel tool in the treatment of Parkinson's disease by enhancing the duration of contralateral rotational behavior with respect to L-DOPA plus vehicle in a dose-related manner.
Oxygen inhalation enhances striatal dopamine metabolism and monoamineoxidase enzyme inhibition prevents it: a microdialysis study.
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