Influence of Psychological Factors on Risk of Temporomandibular Disorders
@article{Slade2007InfluenceOP,
title={Influence of Psychological Factors on Risk of Temporomandibular Disorders},
author={Gary D. Slade and Luda Diatchenko and Konakporn Bhalang and A Sigurdsson and Roger Benton Fillingim and Inna Belfer and Mitchell B. Max and David Goldman and William Maixner},
journal={Journal of Dental Research},
year={2007},
volume={86},
pages={1120 - 1125}
}Psychological characteristics potentially may be a cause or consequence of temporomandibular disorder (TMD). We hypothesized that psychological characteristics associated with pain sensitivity would influence risk of first-onset TMD, but the effect could be attributed to variation in the gene encoding catechol-O-methyltransferase (COMT). We undertook a prospective cohort study of healthy female volunteers aged 18–34 yrs. At baseline, participants were genotyped, they completed psychological…
204 Citations
Psychological factors associated with development of TMD: the OPPERA prospective cohort study.
- PsychologyThe journal of pain : official journal of the American Pain Society
- 2013
COMT Diplotype Amplifies Effect of Stress on Risk of Temporomandibular Pain
- PsychologyJournal of dental research
- 2015
It is hypothesized that temporal escalation in stress exacerbates risk for TMD, and the effect is amplified by allelic variants in a gene, catechol-O-methyltransferase (COMT), regulating catechl neurotransmitter catabolism.
Depressive and anxiety symptoms as risk factors for temporomandibular joint pain: a prospective cohort study in the general population.
- Medicine, PsychologyThe journal of pain : official journal of the American Pain Society
- 2012
Chronic HPA Axis Response to Stress in Temporomandibular Disorder
- Medicine, Biology
- 2013
Despite greater perceived stress, TMD cases had lower hair cortisol concentrations than controls and the 2 measures of stress were weakly and negatively correlated.
Associations between symptoms of temporomandibular disorders, quality of life and psychological states in Asian Military Personnel
- Psychology, MedicineJournal of oral rehabilitation
- 2019
Significant differences in OHRQoL and psychological states were observed between subjects with and without TMD symptoms, and associations between number of T MD symptoms and quality of life, depression, anxiety and stress were significant but weak.
Chronic HPA axis response to stress in temporomandibular disorder.
- MedicineJournal of dental hygiene : JDH
- 2013
Despite greater perceived stress, TMD cases had lower hair cortisol concentrations than controls and the 2 measures of stress were weakly and negatively correlated.
Chronic HPA axis response to stress in temporomandibular disorder.
- MedicineJournal of dental hygiene : JDH
- 2014
Despite greater perceived stress, TMD cases had lower hair cortisol concentrations than controls and the 2 measures of stress were weakly and negatively correlated.
Genomics and the new perspectives for temporomandibular disorders.
- Biology, MedicineArchives of oral biology
- 2011
The risk of temporomandibular disorder in patients with depression: a population-based cohort study.
- Medicine, PsychologyCommunity dentistry and oral epidemiology
- 2011
Patients with depression are at an elevated risk of developing temporomandibular disorder, as demonstrated by a population-based retrospective cohort design.
Psychological correlates of medical comorbidities in patients with temporomandibular disorders.
- Medicine, PsychologyJournal of the American Dental Association
- 2010
Patients with TMDs who have medical comorbidities may be at increased risk of experiencing poor psychological functioning, and dentists routinely should assess not only the symptoms of their T MDs but also their general health status.
References
SHOWING 1-10 OF 37 REFERENCES
Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain: evidence for altered temporal summation of pain
- PsychologyPain
- 1998
Craniofacial muscle pain: review of mechanisms and clinical manifestations.
- MedicineJournal of orofacial pain
- 2001
The literature in which craniofacial muscle pain has been induced by experimental techniques in animals and human volunteers and in which the effects on somatosensory and motor function have been assessed under standardized conditions is reviewed.
First onset of common pain symptoms: a prospective study of depression as a risk factor
- Medicine, PsychologyPain
- 1993
Genetic basis for individual variations in pain perception and the development of a chronic pain condition.
- Medicine, BiologyHuman molecular genetics
- 2005
Three genetic variants of the gene encoding catecholamine-O-methyltransferase determine COMT activity in humans that inversely correlates with pain sensitivity and the risk of developing TMD.
Genetic origins of anxiety in women: a role for a functional catechol-O-methyltransferase polymorphism
- Psychology, MedicinePsychiatric genetics
- 2003
The results of the present study suggest that an inherited difference in catecholamine metabolism is important in the pathogenesis of anxiety in women.
Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli
- Biology, MedicinePain
- 2006
A global measure of perceived stress.
- PsychologyJournal of health and social behavior
- 1983
The Perceived Stress Scale showed adequate reliability and, as predicted, was correlated with life-event scores, depressive and physical symptomatology, utilization of health services, social anxiety, and smoking-reduction maintenance and was a better predictor of the outcome in question than were life- event scores.
COMT val158met Genotype Affects µ-Opioid Neurotransmitter Responses to a Pain Stressor
- Psychology, BiologyScience
- 2003
Individuals homozygous for themet158 allele of the catechol-O-methyltransferase (COMT) polymorphism showed diminished regional μ-opioid system responses to pain compared with heterozygotes, and these effects were accompanied by higher sensory and affective ratings of pain and a more negative internal affective state.
The efficacy of oral splints in the treatment of myofascial pain of the jaw muscles: a controlled clinical trial
- Psychology, MedicinePain
- 1994
A highly significant association between a COMT haplotype and schizophrenia.
- Medicine, PsychologyAmerican journal of human genetics
- 2002
An efficient approach to gene discovery is reported that found a highly significant association between schizophrenia and a COMT haplotype and can be widely implemented for the genetic dissection of other common diseases.



