Influence of Polyphenols on Bacterial Biofilm Formation and Quorum-sensing

  title={Influence of Polyphenols on Bacterial Biofilm Formation and Quorum-sensing},
  author={Birgit E Huber and Leo Eberl and Walter Feucht and J{\"u}rgen Polster},
  journal={Zeitschrift f{\"u}r Naturforschung C},
  pages={879 - 884}
Abstract Many bacteria utilize sophisticated regulatory systems to ensure that some functions are only expressed when a particular population density has been reached. The term ‘quorumsensing’ has been coined to describe this form of density-dependent gene regulation which relies on the production and perception of small signal molecules by bacterial cells. As in many pathogenic bacteria the production of virulence factors is quorum-sensing regulated, it has been suggested that this form of… 
Quorum sensing regulation of gene expression: A promising target for drugs against bacterial pathogenicity
This is a new, alternative strategy of antibacterial therapy, which includes the construction of drugs acting directly against bacterial pathogenicity by suppressing QS (antipathogenicity drugs), which makes it possible to avoid a wide distribution of antibiotic-resistant pathogenic bacteria and the formation of biofilms, which dramatically increase drug resistance.
Quorum sensing: An imperative longevity weapon in bacteria
Quorum sensing mechanism plays a major role in controlling bacterial economy and is a simple, practical and effective mechanism of production and control.
Quorum Sensing in Microbial Virulence
These systems are essential for the design of antimicrobials that could eliminate pathogens or abolish their harmful activities and are essential to analyze the chemical nature of signal molecules used by microorganisms in response to environmental stimuli or need of microbial communities.
Effect of Quorum Sensing Inhibitor Agents against Pseudomonas aeruginosa
The QS mechanism in gram-negative and gram-positive bacteria is discussed with a closer look at the P. aeruginosa infections, where the expression of many virulence factors appears to be controlled by QS.
Quorum sensing inhibitors as anti-biofilm agents.
An overview of QS inhibitors which have been shown to play a role in biofilm formation and/or maturation and proposed as promising antibiofilm agents are given.
Quorum Sensing: A Non-conventional Target for Antibiotic Discovery
It is confirmed that TA can be used as a QSI, either in its purest form or in the crude form found in various plant species, and could be considered for development to compliment antibiotic therapy.
Anti-Quorum Sensing Activity from Ethno Botanical Sources and Their Reduction of Pseudomonas aeruginosa Pathogenicity
The misuse and abuse of antibiotics in pharmacotherapy have led to the development of widespread resistance in the target organism. The failure of existing antibiotics to control infection makes it
Medicinal plant products targeting quorum sensing for combating bacterial infections.
A current overview of the quorum sensing system in bacteria is provided by revealing their implication in biofilms formation and the development of antibiotic resistance, and an update on their importance as a potential target for natural substances is provided.
IBBJ Summer 2018 , Vol 4 , No 3 Quorum Sensing in Microbial Virulence
Cell-to cell communication occurs via a signaling pathway referred to as quorum sensing. There are four main types of these systems according to the chemical nature of signal molecules used by
Natural Anti-Quorum Sensing agents againstPseudomonas aeruginosa
A variety of plants showed their effects on P. aeruginosa virulence by controlling the regulatory QS genes and factors with marginal effects on bacterial growth as well as the quorum-quenching mechanisms, which are unrelated to static or cidal effects.


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