Influence of Paternal 252Cf Neutron Exposure on Abnormal Sperm, Embryonal Lethality, and Liver Tumorigenesis in the F1 Offspring of Mice

@inproceedings{Watanabe1996InfluenceOP,
  title={Influence of Paternal 252Cf Neutron Exposure on Abnormal Sperm, Embryonal Lethality, and Liver Tumorigenesis in the F1 Offspring of Mice},
  author={Hiromitsu Watanabe and Tadateru Takahashi and J Lee and Megu Ohtaki and Goutam Roy and Yasumi Ando and Kazumasa Yamada and Takahiko Gotoh and Kazunobu Kurisu and Nariaki Fujimoto and Yukio Satow and Akihiro Ito},
  booktitle={Japanese journal of cancer research : Gann},
  year={1996}
}
Experiments were conducted to determine whether neutron-induced genetic damage in parental germline cells can lead to development of cancer in the offspring. Seven-week-old C3H male mice were irradiated with (252) Cf neutrons at a dose of 0, 50, 100, or 200 cGy. Two weeks or three months after irradiation, the male mice were mated with virgin 9-week-old C57BL females. Two weeks after irradiation, the irradiated male mice showed an increased incidence of sperm abnormalities, which led to embryo… CONTINUE READING