Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients

@article{Gao2014InfluenceOP,
  title={Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients},
  author={Li-chen Gao and Dilan Wang and Fang-qun Liu and Zheng-yu Huang and Hong-guang Huang and Guichao Wang and X. Chen and Qun-zhi Shi and Li Hong and Li-ping Wu and Jie Tang},
  journal={European Journal of Clinical Pharmacology},
  year={2014},
  volume={71},
  pages={43-50}
}
PurposeThe purpose of this study is to evaluate the association between variants in prostaglandin-endoperoxide synthase 1 (PTGS1), prostaglandin F (2α) receptor (PTGFR), and multidrug resistance protein 4 (MRP4) genes and intraocular pressure (IOP) response to latanoprost in Chinese patients with primary open-angle glaucoma (POAG).MethodsThe IOP response to latanoprost was evaluated by percent IOP reduction (%ΔIOP) in the treated eye with the formula %ΔIOP = (Baseline IOP values − IOP values… 
PTGFR and SLCO2A1 Gene Polymorphisms Determine Intraocular Pressure Response to Latanoprost in Han Chinese Patients with Glaucoma
TLDR
An association was found between single nucleotide polymorphisms of the PTGFR and SLCO2A1 genes and the response to latanoprost in Han Chinese patients with glaucoma.
Correlations of AFAP1, GMDS and PTGFR gene polymorphisms with intra‐ocular pressure response to latanoprost in patients with primary open‐angle glaucoma
TLDR
This study aimed to explore possible correlations of common single nucleotide polymorphisms in AFAP1, GMDS and PTGFR genes with intra‐ocular pressure (IOP) response to latanoprost in POAG patients.
Ocular hypotensive effects of prostaglandin analogs in Japanese patients with normal-tension glaucoma: a literature review
TLDR
Ophthalmologists should understand the IOP-lowering profiles of various PGAs and apply them to patients with NTG on a case-by-case basis.
Next-Generation Sequencing of PTGS Genes Reveals an Increased Frequency of Non-synonymous Variants Among Patients With NSAID-Induced Liver Injury
TLDR
An interaction of long-term exposure to COX inhibitors combined with functional variants of the COX enzymes in the risk of developing DILI is suggested.
Pharmacogenomics of Prostaglandin and Leukotriene Receptors
TLDR
SNPs in PTGs and LTs receptors and their relevance in human diseases are summarized and information on gene expression is provided to speculate on future directions for this topic.
Pharmacogenomics of cyclooxygenases.
TLDR
This work analyses major variations in the PTGS1 and PTGS2 genes, allele frequencies, functional consequences and population genetics, and provides an up-to-date catalog of PTGS clinical associations based on case-control studies and genome-wide association studies, and future research suggestions.
Effects of sustained daily latanoprost application on anterior chamber anatomy and physiology in mice
TLDR
It is shown that latanoprost initially lowered IOP in C57BL/6J mice, but became less effective with sustained treatment, likely due to physiological adaptation.
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