Influence of PGE2- and cAMP-modulating agents on human glioblastoma cell killing by interleukin-2-activated lymphocytes.

@article{Kuppner1990InfluenceOP,
  title={Influence of PGE2- and cAMP-modulating agents on human glioblastoma cell killing by interleukin-2-activated lymphocytes.},
  author={Maria C. Kuppner and Yutaka Sawamura and M. F. Hamou and Nicolas de Tribolet},
  journal={Journal of neurosurgery},
  year={1990},
  volume={72 4},
  pages={619-25}
}
Human glioblastoma cells secrete factors, such as prostaglandin E (PGE) and transforming growth factor beta type 2, which are capable of suppressing several immune functions. The present study investigated the effect of PGE2 and agents known to increase intracellular cyclic adenosine monophosphate (cAMP) levels on 1) the induction of lymphokine-activated killer (LAK) cell activity from the peripheral blood lymphocytes (PBL) of both normal and glioma patients and on 2) the cytolytic activities… CONTINUE READING