Influence of PEG coating on the oral bioavailability of gold nanoparticles in rats.

@article{Alalaiwe2017InfluenceOP,
  title={Influence of PEG coating on the oral bioavailability of gold nanoparticles in rats.},
  author={Ahmed Alalaiwe and Georgia M. Roberts and Paul L. Carpinone and John W Munson and Stephen M Roberts},
  journal={Drug delivery},
  year={2017},
  volume={24 1},
  pages={
          591-598
        }
}
Metallic nanoparticles can be produced in a variety of shapes, sizes, and surface chemistries, making them promising potential tools for drug delivery. Most studies to date have evaluated uptake of metallic nanoparticles from the GI tract with methods that are at best semi-quantitative. This study used the classical method of comparing blood concentration area under the curve (AUC) following intravenous and oral doses to determine the oral bioavailability of 1, 2 and 5 kDa PEG-coated 5 nm gold… CONTINUE READING