Influence of P-glycoprotein modulation on plasma concentrations and pharmacokinetics of orally administered prednisolone in dogs.

@article{Heyden2012InfluenceOP,
  title={Influence of P-glycoprotein modulation on plasma concentrations and pharmacokinetics of orally administered prednisolone in dogs.},
  author={Sara Van der Heyden and Siska Croubels and Caroline Gadeyne and Richard Ducatelle and Sylvie Daminet and Hugo Murua Escobar and Katharina Anna Sterenczak and Ingeborgh E Polis and Stijn Schauvliege and Myriam Hesta and Koen Chiers},
  journal={American journal of veterinary research},
  year={2012},
  volume={73 6},
  pages={
          900-7
        }
}
OBJECTIVE To evaluate the impact of modulation of the membrane-bound efflux pump P-glycoprotein (P-gp) on plasma concentrations of orally administered prednisolone in dogs. ANIMALS 7 healthy adult Beagles. PROCEDURES Each dog received 3 treatments (control [no treatment], rifampicin [100 mg/d, PO, for 21 days, as an inducer of P-gp], and ketoconazole [100 mg/d, PO, for 21 days, as an inhibitor of P-gp]). A single dose of prednisolone (1 mg/kg, PO) was administered on day 8 of each treatment… CONTINUE READING