Influence of Oxygen Tension on Dopaminergic Differentiation of Human Fetal Stem Cells of Midbrain and Forebrain Origin

@inproceedings{Krabbe2014InfluenceOO,
  title={Influence of Oxygen Tension on Dopaminergic Differentiation of Human Fetal Stem Cells of Midbrain and Forebrain Origin},
  author={Christina Krabbe and Sara Thornby Bak and Pia V Jensen and Christian Ulrich von Linstow and Alberto Mart{\'i}nez Serrano and Claus Rosenkrantz Hansen and Morten Meyer},
  booktitle={PloS one},
  year={2014}
}
Neural stem cells (NSCs) constitute a promising source of cells for transplantation in Parkinson's disease (PD), but protocols for controlled dopaminergic differentiation are not yet available. Here we investigated the influence of oxygen on dopaminergic differentiation of human fetal NSCs derived from the midbrain and forebrain. Cells were differentiated for 10 days in vitro at low, physiological (3%) versus high, atmospheric (20%) oxygen tension. Low oxygen resulted in upregulation of… CONTINUE READING

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