Influence of NG-monomethyl-L-arginine on endothelium-dependent relaxations in the perfused mesenteric vascular bed of the rat.

@article{Ebeigbe1990InfluenceON,
  title={Influence of NG-monomethyl-L-arginine on endothelium-dependent relaxations in the perfused mesenteric vascular bed of the rat.},
  author={Anthony B. Ebeigbe and Floriane Cressier and M K Konneh and T. D. C. Luu and Leoluca Criscione},
  journal={Biochemical and biophysical research communications},
  year={1990},
  volume={169 3},
  pages={
          873-9
        }
}
The role of nitric oxide and potassium channels in endothelium-dependent vasodilation in SHR.
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It is concluded that endothelium-derived relaxing factor is only partially responsible for the endothelia-dependent vasodilation of methacholine-induced vasodilated rats.
Differential effect of nitric oxide synthase inhibitors on acetylcholine-induced relaxation of rat pulmonary and celiac artery rings.
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In the pulmonary artery nitric oxide plays a greater role in the modulation of baseline vascular tone and ACh-induced relaxation than in the celiac artery, and cyclooxygenase products do not contribute to the direct contractile responses to L-NAME and L-NMMA.
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It was observed that ACh significantly decreased the vascular resistance and increased dermal capillary perfusion in norepinephrine (NE, 10(-6) M) preconstricted skin flaps, despite the presence of a cyclooxygenase inhibitor and a beta-adrenergic receptor antagonist.
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An increase in endothelium‐dependent blood flow stimulated by ACh may occur in diaphragmatic microcirculation of anaesthetized rats independently of low baseline NO activity, and the results suggest that l‐NAME has muscarinic receptor antagonist action in addition to its ability to inhibit NO synthase.
Local inhibition of nitric oxide generation in man reduces blood flow in finger pulp but not in hand dorsum skin.
TLDR
The results suggest that endogenous nitric oxide production may be more important in regulating microvascular skin blood flow in regions rich in arteriovenous anastomoses than in areas containing mainly nutritive vessels.
VASCULAR REACTIVITY TO VASOACTIVE AGENTS FOLLOWING EXPOSURE TO KOLAVIRON IN ISOLATED AORTIC RINGS
TLDR
Kolaviron causes smooth muscle relaxation in arterial blood vessel of rabbit aorta in a concentration-dependent manner in non-specific mode of action and may not be unconnected with guanylate cyclase enzyme-cGMP pathway, calcium supply blockade and Na+-K+ ATPase cellular activity.
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