Influence of NAD-linked dehydrogenase activity on flux through oxidative phosphorylation.

  title={Influence of NAD-linked dehydrogenase activity on flux through oxidative phosphorylation.},
  author={Rafael Moreno-S{\'a}nchez and Barbara A. Hogue and Richard G N Hansford},
  journal={The Biochemical journal},
  volume={268 2},
1. We have examined systematically the relationship between the percentage reduction of cardiac mitochondrial NAD and the flux through oxidative phosphorylation, as measured by O2 uptake. Reduction of NAD was varied by varying the concentration of palmitoyl-L-carnitine, pyruvate, 2-oxoglutarate or glutamate in the presence of malate as the oxidizable substrate. 2. In the presence of ADP (State 3 respiration) there was a substantially linear positive relationship between O2 uptake and the… CONTINUE READING
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