• Corpus ID: 37799190

Influence of Moringa oleifera on Non-Alcoholic Fatty Liver in Adult Albino Rats

@inproceedings{Halaby2015InfluenceOM,
  title={Influence of Moringa oleifera on Non-Alcoholic Fatty Liver in Adult Albino Rats},
  author={Mona S. Halaby and Maha Mohamed Essam El-din and Nada Emara},
  year={2015}
}

• M. Halaby, M. M. El-din, Nada Emara
• Published 2015

The main target of this study was to investigate the beneficial effects of Moringa oleifera (MO) (leaves and roots) on nutritional values, protection against oxidative stress and hepato protective activity of non alcoholic fatty liver disease (NAFLD) in adult albino rats. Forty-two rats were used in this experiment. These rats were put on ideal diet for one week before the performance of the experiment. At the beginning, these rats were divided into 6 main groups (seven rats of each) and fed on diets for 4 weeks as follows: The first group was fed on the basal diet as a (negative control group). The second group was fed on the basal diet with high fat diet (HFD) to induce fatty liver (positive control group). The third and fourth groups contained the same composition as positive diet, in addition (1.5%) and (3%) MO roots powder. The fifth and sixth groups contained the same composition as positive diet, in addition (1.5%) and (3%) MO leaves powder. At the end of the experimental period rats were fasted overnight and sacrificed, blood samples were collected from the aorta to determine total cholesterol and other lipids, also for liver and kidney functions. Besides, nutritional parameters were recorded including body weight gain, feed intake and feed efficiency ratio. Also, liver was removed surgically for histopathological observation. From the obtained results we concluded that group of rats fed on HFD were considered as a major risk factor for fatty liver disease. Our results could be summarized that diet fortified at 3% leaves or roots can reduced blood cholesterol and other lipids as well as reducing hazards on liver and kidney function compared with positive control group and improved the body weight gain and feed intake.