Influence of Molecular Weight of Carriers and Processing Parameters on the Extrudability, Drug Release, and Stability of Fenofibrate Formulations Processed by Hot-Melt Extrusion.

Abstract

The objective of this study was to investigate the extrudability, drug release, and stability of fenofibrate (FF) formulations utilizing various hot-melt extrusion processing parameters and polyvinylpyrrolidone (PVP) polymers of various molecular weights. The different PVP grades selected for this study were Kollidon® 12 PF (K12), Kollidon® 30 (K30), and… (More)

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@article{Alsulays2015InfluenceOM, title={Influence of Molecular Weight of Carriers and Processing Parameters on the Extrudability, Drug Release, and Stability of Fenofibrate Formulations Processed by Hot-Melt Extrusion.}, author={Bader B. Alsulays and Jun-Bom Park and Sultan Alshehri and Joseph T. Morott and Saad M. Alshahrani and Roshan Vijay Tiwari and Abdullah S. Alshetaili and Soumyajit Majumdar and Nigel Langley and Karl Kolter and Andreas Gryczke and Michael A. Repka}, journal={Journal of drug delivery science and technology}, year={2015}, volume={29}, pages={189-198} }