Influence of Matrigel-overlay on constitutive and inducible expression of nine genes encoding drug-metabolizing enzymes in primary human hepatocytes.

@article{GrossSteinmeyer2005InfluenceOM,
  title={Influence of Matrigel-overlay on constitutive and inducible expression of nine genes encoding drug-metabolizing enzymes in primary human hepatocytes.},
  author={Kerstin Gross-Steinmeyer and Patricia L. Stapleton and Julia Helen Tracy and Theo K. Bammler and Tom Lehman and Stephen C Strom and Daniel L. Eaton},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2005},
  volume={35 5},
  pages={
          419-38
        }
}
1. Previous studies reported that rat hepatocytes overlaid with extracellular matrix components (Matrigel) maintain the expression and responsiveness of drug-metabolizing enzymes. However, whether Matrigel provides similar advantages in human hepatocytes remains largely uncertain.2. The influence of Matrigel-overlay on the constitutive and phenobarbital- and oltipraz-inducible expression of nine biotransformation enzymes, cytochrome P450s 1A1, 1A2, 2B6, 3A4, and glutathione S-transferases A1… CONTINUE READING

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