Influence of Malnutrition on the Pharmacokinetics of Drugs Used in the Treatment of Poverty-Related Diseases: A Systematic Review

@article{Verrest2021InfluenceOM,
  title={Influence of Malnutrition on the Pharmacokinetics of Drugs Used in the Treatment of Poverty-Related Diseases: A Systematic Review},
  author={Luka Verrest and Erica A. Wilthagen and Jos H. Beijnen and Alwin D. R. Huitema and Thomas P. C. Dorlo},
  journal={Clinical Pharmacokinetics},
  year={2021},
  volume={60},
  pages={1149 - 1169}
}
Patients affected by poverty-related infectious diseases (PRDs) are disproportionally affected by malnutrition. To optimize treatment of patients affected by PRDs, we aimed to assess the influence of malnutrition associated with PRDs on drug pharmacokinetics, by way of a systematic review. A systematic review was performed on the effects of malnourishment on the pharmacokinetics of drugs to treat PRDs, including HIV, tuberculosis, malaria, and neglected tropical diseases. In 21/29 PRD drugs… 
2 Citations

Clinical standards for the dosing and management of TB drugs

  • J. AlffenaarS. Stocker G. Migliori
  • Medicine
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
  • 2022
TLDR
This is the first consensus-based Clinical Standards for the dosing and management of TB drugs to guide clinicians and programme managers in planning and implementation of locally appropriate measures for optimal person-centred treatment to improve patient care.

Antimalarial treatment in infants.

TLDR
Additional evidence on the efficacy, safety, tolerability, acceptability and effectiveness of ACTs in infants is needed, as well as population pharmacokinetics studies on antimalarials in the infant population.

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