Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression

@article{Delacrtaz2015InfluenceOM,
  title={Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression},
  author={Aur{\'e}lie Delacr{\'e}taz and Martin Preisig and Frederik Vandenberghe and Nuria Saigi Morgui and Lina Quteineh and Eva Choong and Mehdi Gholam-Rezaee and Zolt{\'a}n Kutalik and Pierre Julius Magistretti and Jean-Michel Aubry and Armin von Gunten and Enrique Castelao and Peter Vollenweider and G{\'e}rard Waeber and Philippe Conus and Chin B. Eap},
  journal={PLoS ONE},
  year={2015},
  volume={10}
}
Obesity development during psychotropic treatments represents a major health issue in psychiatry. Melanin-concentrating hormone receptor 2 (MCHR2) is a central receptor involved in energy homeostasis. MCHR2 shares its promoter region with MCHR2-AS1, a long antisense non-coding RNA. The aim of this study was to determine whether tagging single nucleotide polymorphisms (tSNPs) of MCHR2 and MCHR2-AS1 are associated with the body mass index (BMI) in the psychiatric and in the general population… 
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A défaut, tout contrevenant s'expose aux sanctions prévues par cette loi, nous déclinons toute responsabilité en la matière.
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