Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene

@article{Caspi2003InfluenceOL,
  title={Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene},
  author={Avshalom Caspi and Karen Sugden and Terrie E. Moffitt and Alan H. Taylor and Ian W. Craig and HonaLee Harrington and Joseph L. McClay and Jonathan S Mill and Judith Martin and Antony Braithwaite and Richie Poulton},
  journal={Science},
  year={2003},
  volume={301},
  pages={386 - 389}
}
In a prospective-longitudinal study of a representative birth cohort, we tested why stressful experiences lead to depression in some people but not in others. A functional polymorphism in the promoter region of the serotonin transporter (5-HT T) gene was found to moderate the influence of stressful life events on depression. Individuals with one or two copies of the short allele of the 5-HT T promoter polymorphism exhibited more depressive symptoms, diagnosable depression, and suicidality in… 

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