Influence of Lewis alpha1-3/4-L-fucosyltransferase (FUT3) gene mutations on enzyme activity, erythrocyte phenotyping, and circulating tumor marker sialyl-Lewis a levels.

@article{Orntoft1996InfluenceOL,
  title={Influence of Lewis alpha1-3/4-L-fucosyltransferase (FUT3) gene mutations on enzyme activity, erythrocyte phenotyping, and circulating tumor marker sialyl-Lewis a levels.},
  author={Torben Falck Orntoft and Else Marie Vestergaard and E. W. Holmes and Janus S Jakobsen and Niels Grunnet and Martin Mortensen and Philip I Johnson and Peter Bross and N. Gregersen and K M Skorstengaard and Uffe Birk Jensen and Lars Bolund and H. -R. Wolf},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 50},
  pages={32260-8}
}
Fucosylated glycoproteins carrying alpha1-4 fucose residues are of importance for cell adhesion and as tumor markers. The Lewis gene, FUT3, encodes the only known alpha1-4-fucosyltransferase (FucT), and individuals who are deficient in this enzyme type as Lewis-negative on erythrocytes. We examined the mutational spectrum of the Lewis gene in Denmark and found 6 different mutations. Five, T59G, T202C, C314T, G508A, and T1067A, were frequent, and one, C445A, was only detected in one out of 40… CONTINUE READING

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