Influence of JC virus coding region genotype on risk of multiple sclerosis and progressive multifocal leukoencephalopathy.

@article{Agostini2000InfluenceOJ,
  title={Influence of JC virus coding region genotype on risk of multiple sclerosis and progressive multifocal leukoencephalopathy.},
  author={H. T. Agostini and Caroline F. Ryschkewitsch and RobertW. Baumhefner and Wallace W. Tourtellotte and Elyse J. Singer and S{\'a}muel Komoly and Gerald L. Stoner},
  journal={Journal of neurovirology},
  year={2000},
  volume={6 Suppl 2},
  pages={
          S101-8
        }
}
Two features of the biology of JC virus make it a particularly suitable candidate for an agent in MS-like disease: its neurotropic capability targeting glial cells as evidenced in progressive multifocal leukoencephalopathy lesions, and its capacity for latency and persistence as illustrated by its behaviour in the kidney. JC virus is chronically or intermittently excreted in the urine by some 40% of the population. The existence of JC virus in multiple coding-region genotypes provides a unique… CONTINUE READING
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