Influence of Human Serum Albumin on Photodegradation of Folic Acid in Solution

@inproceedings{Vorobey2006InfluenceOH,
  title={Influence of Human Serum Albumin on Photodegradation of Folic Acid in Solution},
  author={Pavel Vorobey and Arnfinn Engeset Steindal and Morten Kristian Off and Alexander Vorobey and Johan Emelian Moan},
  booktitle={Photochemistry and photobiology},
  year={2006}
}
Abstract It has been proposed that photodegradation of folates may be the reason for the pigmentation of races living under high fluence rates of ultraviolet radiation. The photodegradation of folic acid (FA) induced by ultraviolet-A (UV-A) radiation, in solution and in the presence of human serum albumin (HSA), was studied with absorption and fluorescence spectroscopy. FA photodegradation, with formation of p-aminobenzoyl-l-glutamic acid, 6-formylpterin and pterin-6-carboxylic acid, was found… 
The action spectrum for folic acid photodegradation in aqueous solutions.
Insight into the interaction of human serum albumin with folic acid: A biophysical study.
Photoinactivation of tyrosinase sensitized by folic acid photoproducts.
Interaction between the photosensitizer lumichrome and human serum albumin: effect of excipients
TLDR
A modest interaction between Lc and HSA which was reduced mainly by HPβCD was showed and no major alterations of the HSA nano-DSC thermogram was found.
Interaction between the photosensitizer lumichrome and human serum albumin: effect of excipients
TLDR
HαCD, HPγCD and PEG400 seemed to be the excipients more suitable for use in topical preparations containing Lc, which showed a modest interaction between Lc and HSA which was reduced mainly by HPβCD.
5-Methyltetrahydrofolate can be photodegraded by endogenous photosensitizers.
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