Influence of HAART on Alternative Reading Frame Immune Responses over the Course of HIV-1 Infection

@inproceedings{Champiat2012InfluenceOH,
  title={Influence of HAART on Alternative Reading Frame Immune Responses over the Course of HIV-1 Infection},
  author={St{\'e}phane Champiat and Rui Andr{\'e} Saraiva Raposo and Nicholas James Maness and John L. Lehman and Sean E. Purtell and Aaron M. Hasenkrug and Jacob Miller and Hansi J. Dean and Wayne Chester Koff and Marisa Ailin Hong and Jeffrey N Martin and Steven G. Deeks and Gerald E. Spotts and Christopher D. Pilcher and Fredrick M. Hecht and Esper G Kallas and Keith Garrison and Douglas F Nixon},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Translational errors can result in bypassing of the main viral protein reading frames and the production of alternate reading frame (ARF) or cryptic peptides. Within HIV, there are many such ARFs in both sense and the antisense directions of transcription. These ARFs have the potential to generate immunogenic peptides called cryptic epitopes (CE). Both antiretroviral drug therapy and the immune system exert a mutational pressure on HIV-1. Immune pressure exerted by ARF CD8(+) T cells… CONTINUE READING
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Enhanced Recognition of HIV-1 Cryptic Epitopes Restricted by HLA Class I Alleles Associated With a Favorable Clinical Outcome.

  • Journal of acquired immune deficiency syndromes
  • 2015
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