Influence of Glucose on the Transmembrane Action Potential of Anoxic Papillary Muscle

@article{Macleod1965InfluenceOG,
  title={Influence of Glucose on the Transmembrane Action Potential of Anoxic Papillary Muscle},
  author={D P Macleod and Edwin E. Daniel},
  journal={The Journal of General Physiology},
  year={1965},
  volume={48},
  pages={887 - 899}
}
The response of the cat papillary muscle to anoxia has been found to alter depending on the glucose concentration in the medium. At a glucose concentration of 5 mM anoxia caused a marked reduction in force of contraction and action potential duration within 20 minutes. At a glucose concentration of 50 mM anoxia induced similar changes in the force of contraction but little or no change in action potential duration. Elevation of glucose concentration during an anoxic interval reversed the anoxia… CONTINUE READING

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