Influence of Gastrointestinal Site of Drug Delivery on the Absorption Characteristics of Ranitidine

@article{Williams1992InfluenceOG,
  title={Influence of Gastrointestinal Site of Drug Delivery on the Absorption Characteristics of Ranitidine},
  author={Melissa F. Williams and George E. Dukes and William D. Heizer and Yieng-Hau Han and David J. Hermann and Thomas A. Lampkin and Lawrence J. Hak},
  journal={Pharmaceutical Research},
  year={1992},
  volume={9},
  pages={1190-1194}
}
The absorption characteristics of ranitidine after delivery to three locations in the gastrointestinal tract were compared in an open-label study of eight healthy males. Subjects received ranitidine HCl (150 mg) for injection via a nasoenteric tube directly into their stomach, jejunum, or cecum sequentially in three separate periods (24 hr apart). Plasma samples were collected at periodic time intervals for 12 hr following each dosing and analyzed for ranitidine concentration by high-pressure… CONTINUE READING