Influence of GSTT1 genotype on sister chromatid exchange induction by styrene-7,8-oxide in cultured human lymphocytes.

@article{Ollikainen1998InfluenceOG,
  title={Influence of GSTT1 genotype on sister chromatid exchange induction by styrene-7,8-oxide in cultured human lymphocytes.},
  author={Tiina Ollikainen and Ari P Hirvonen and Hannu Norppa},
  journal={Environmental and molecular mutagenesis},
  year={1998},
  volume={31 4},
  pages={311-5}
}
The genetic polymorphisms of glutathione S-transferases (GSTs), which are involved in the metabolic inactivation of various toxicants, have been suggested to be an important source of variation in individual response to genotoxic carcinogens. We have previously shown that donor GSTM1 genotype does not influence the induction of sister chromatid exchanges (SCEs) in cultured human lymphocytes by styrene-7,8-oxide (SO), a metabolite of styrene. Here, we expanded the study to GSTT1 polymorphism… CONTINUE READING

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