Influence of GSTM1, GSTT1, GSTP1, NAT1, NAT2, EPHX1, MTR and MTHFR polymorphism on chromosomal aberration frequencies in human lymphocytes.
@article{Skjelbred2011InfluenceOG, title={Influence of GSTM1, GSTT1, GSTP1, NAT1, NAT2, EPHX1, MTR and MTHFR polymorphism on chromosomal aberration frequencies in human lymphocytes.}, author={C. Skjelbred and Marit Svendsen and V. Haugan and A. K. Eek and K. O. Clausen and E. Kure and J. Tuimala and M. Svendsen and H. Norppa and Inger-Lise Hansteen}, journal={Carcinogenesis}, year={2011}, volume={32 3}, pages={ 399-405 } }
We have studied the influence of genetic polymorphisms in the xenobiotic-metabolizing genes GSTM1, GSTP1, GSTT1, EPHX1, NAT1 and NAT2 and the folate-metabolizing genes MTR and MTHFR on the frequencies of cells with chromosomal aberrations (CAs) in peripheral lymphocytes of Norwegian men. Log-linear Poisson regression models were applied on 357 subjects of whom data on all the polymorphisms examined were available. Total CAs and chromosome-type aberrations (CSAs) were significantly increased by… CONTINUE READING
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