Influence of ESR1 variants on clinical characteristics and fibromyalgia syndrome in Turkish women.

@article{Arslan2020InfluenceOE,
  title={Influence of ESR1 variants on clinical characteristics and fibromyalgia syndrome in Turkish women.},
  author={Hamide Arslan and Ayşe Feyda Nursal and Ahmet Inanir and Nevin Karakuş and Serbulent Yigit},
  journal={Endocrine, metabolic \& immune disorders drug targets},
  year={2020}
}
  • H. Arslan, A. Nursal, S. Yigit
  • Published 10 September 2020
  • Medicine, Biology
  • Endocrine, metabolic & immune disorders drug targets
BACKGROUND Fibromyalgia syndrome (FMS) is characterized by widespread musculoskeletal pain. It is more common in women than in men, and sex hormones may play a role in this predominance. Therefore, this research investigated whether Estrogen-α (ESR1) gene variants are associated with FMS and clinical findings among Turkish females. Methods: A total of 219 individuals were enrolled in this study. ESR1 variants (PvuII/XbaI) were genotyped using PCRRFLP methods. The results of the analyses were… 
1 Citations
Endogenous estrogen deficiency and the development of chronic musculoskeletal pain: A review
TLDR
A decrease in estrogen levels associated with menopause or iatrogenic effects (hysterectomy, use of aromotase inhibitors), as well as mutations of genes responsible for the synthesis of structural components of membrane estrogen receptors (ESR1 and ESR2), can significantly reduce the positive effects of these hormones.