Influence of E3 region on conditionally replicative adenovirus mediated cytotoxicity in hepatocellular carcinoma cells

@article{Lu2009InfluenceOE,
  title={Influence of E3 region on conditionally replicative adenovirus mediated cytotoxicity in hepatocellular carcinoma cells},
  author={Qin Lu and De-Hong Yu and Chao Fang and Fang Liu and Xun Ye and Yi Zhao and Jie Qin and Xiaoni Guo and Min Liang and Fang Hu and Hong-Zhuan Chen},
  journal={Cancer Biology \& Therapy},
  year={2009},
  volume={8},
  pages={1125 - 1132}
}
Virotherapy employing conditionally replicative adenovirus (CRAd) represents a novel targeted strategy for the hepatocellular carcinoma (HCC) treatment. In this study, we explored the potential influence of E3 region, which encodes several TRAIL-inhibiting proteins (E3-6.7K, E3-10.4K/14.5K and E3-14.7K), on CRAd mediated cytotoxicity to HCC cells. Two E1B-55 kDa-deleted CRAds containing E3 region (Ad.ΔE1B) or no E3 region (Ad.ΔE1B.ΔE3) were fabricated. Ad.ΔE1B.ΔE3 exhibited higher cytocidal… 
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Adenoviral gene therapy in hepatocellular carcinoma: a review

An update of what has been accomplished in the field of adenoviral gene therapy and its application in hepatocellular carcinoma treatment is provided to provide an opportunity to improve the quality of life and survival of HCC patients.

Adenovirus E3 proteins help tumors to evade innate and adaptive immune responses

Influence of E3 region on conditionally replicative adenovirus mediated cytotoxicity in hepatocellular carcinoma cells is studied.

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