Influence of Dosing Schedule on Organ Exposure to Cyclosporin in Pediatric Hematopoietic Stem Cell Transplantation: Analysis with a PBPK Model

@article{Grard2010InfluenceOD,
  title={Influence of Dosing Schedule on Organ Exposure to Cyclosporin in Pediatric Hematopoietic Stem Cell Transplantation: Analysis with a PBPK Model},
  author={C{\'e}cile G{\'e}rard and Nathalie Bleyzac and Pascal Girard and Gilles Freyer and Yves Bertrand and Michel Tod},
  journal={Pharmaceutical Research},
  year={2010},
  volume={27},
  pages={2602-2613}
}
Cyclosporin is administered by intermittent infusions (II) or continuous infusions (CI) to prevent acute graft-versus-host disease (aGVHD). Because cyclosporin disposition is nonlinear, organ exposure may be higher after II than after CI, but saturation of receptors must be accounted for. The aim of the study was to compare both types of administration using a mechanistic model. A physiologically based pharmacokinetic model was developed to estimate cyclosporin exposure and receptor occupancies… CONTINUE READING
7 Citations
42 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Similar Papers

Loading similar papers…