Influence of Dexmedetomidine on Toxicity of Intrathecal Ketamine on Neonatal Rat Spinal Function

  title={Influence of Dexmedetomidine on Toxicity of Intrathecal Ketamine on Neonatal Rat Spinal Function},
  author={Yueyi Ren and Hai-qing Zhang and Shu-Hua Duan and Shi-duan Wang},
  journal={Tropical Journal of Pharmaceutical Research},
Purpose : To investigate the influence of dexmedetomidine on the effect of ketamine on developing spinal cord. Methods : Postnatal day 3 (P3) and postnatal day 7 (P7) rat pups received intrathecal ketamine (10 mg/kg b.wt) and/or dexmedetomidine (10 μg/kg b.wt). Spinal reflex function was assessed by evaluating the sensory stimuli based on mechanical withdrawal threshold. Spinal tissue was analysed for activated caspase-3 using monoclonal anti-activated caspase-3. Apoptosis count of the spinal… Expand
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