Influence of Desmopressin on water-salt homeostasis and the orthostatic tolerance during head-down tilting

Abstract

Influence of Desmopressin, a synthetic analog of antidiuretic hormone (ADH), on the water-salt metabolism and orthostatic tolerance in humans during head-down tilting (HDT 15°) for 24 h has been studied. Smaller decrease in the total body water and extracellular fluid content, suppression of diuresis, and positive water balance were observed after Desmopressin administration as compared to the control group (without ADH). At the same time, the tolerance of the standard orthostatic test is increased. Thus, Desmopressin has been shown to prevent hypohydration of the body under the HDT conditions and, hence, an increase of orthostatic tolerance.

DOI: 10.1134/S0362119711070206

2 Figures and Tables

Cite this paper

@article{Larina2011InfluenceOD, title={Influence of Desmopressin on water-salt homeostasis and the orthostatic tolerance during head-down tilting}, author={Irina M. Larina and Vitalij B Noskov and I. A. Nichiporuk and Lyudmila Kh. Pastushkova and G. Yu. Vasil’eva}, journal={Human Physiology}, year={2011}, volume={37}, pages={875-878} }