Influence of Defined Hydrophilic Blocks within Oligoaminoamide Copolymers : Compaction versus Shielding of pDNA Nanoparticles

Abstract

Cationic polymers are promising components of the versatile platform of non-viral nucleic acid (NA) delivery agents. For a successful gene delivery system, these NA vehicles need to comprise several functionalities. This work focuses on the modification of oligoaminoamide carriers with hydrophilic oligomer blocks mediating nanoparticle shielding potential… (More)

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