Influence of DNA repair gene polymorphisms of hOGG1, XRCC1, XRCC3, ERCC2 and the folate metabolism gene MTHFR on chromosomal aberration frequencies.

  title={Influence of DNA repair gene polymorphisms of hOGG1, XRCC1, XRCC3, ERCC2 and the folate metabolism gene MTHFR on chromosomal aberration frequencies.},
  author={C. Skjelbred and Marit Svendsen and V. Haugan and A. K. Eek and K. O. Clausen and M. Svendsen and Inger-Lise Hansteen},
  journal={Mutation research},
  volume={602 1-2},
  • C. Skjelbred, Marit Svendsen, +4 authors Inger-Lise Hansteen
  • Published 2006
  • Biology, Medicine
  • Mutation research
  • We have studied the effect of genetic polymorphisms in the DNA repair genes hOGG1, XRCC1, XRCC3, ERCC2 and the MTHFR gene in the folate metabolism on the frequencies of cells with chromosomal aberrations (CA), chromosome-type aberrations (CSA), chromatid-type aberrations (CTA), chromatid breaks (CTB) and chromatid gaps (CTG) scored in peripheral blood lymphocytes from 651 Norwegian subjects of Caucasian descendant. DNA was extracted from fixed cell suspensions. The log-linear Poisson regression… CONTINUE READING
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