Influence of Characteristics of Oily Vehicle on Skin Penetration of Ufenamate.

  title={Influence of Characteristics of Oily Vehicle on Skin Penetration of Ufenamate.},
  author={Hayato Iino and M. Fujii and Manami Fujino and Shizuka Kohara and K. Hashizaki and Hitomi Kira and N. Koizumi and Yoshiteru Watanabe and N. Utoguchi},
  journal={Biological \& pharmaceutical bulletin},
  volume={40 2},
Skin penetration amounts of a highly lipophilic drug, ufenamate, prepared in four oily vehicles, including white petrolatum (WP), liquid paraffin (LP), isopropyl myristate (IPM), and isocetyl stearate (ICS), were compared. Ufenamate was mixed in each vehicle at 5% and applied at a rate of 2 mg/cm2 to intact, stripped, and delipidized Yucatan micropig skin. The amounts of ufenamate and IPM in the stratum corneum (SC), epidermis, and dermis were determined. The skin penetration amounts of… Expand
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