Influence of CYP3A4, CYP3A5 and MDR-1 polymorphisms on tacrolimus pharmacokinetics and early renal dysfunction in liver transplant recipients.

@article{Shi2013InfluenceOC,
  title={Influence of CYP3A4, CYP3A5 and MDR-1 polymorphisms on tacrolimus pharmacokinetics and early renal dysfunction in liver transplant recipients.},
  author={Yunying Shi and Yi Li and Jiangtao Tang and Junlong Zhang and Yuangao Zou and Bei Cai and Lanlan Wang},
  journal={Gene},
  year={2013},
  volume={512 2},
  pages={226-31}
}
OBJECTIVES Tacrolimus is a widely used immunosuppressive drug in organ transplantation. The oral bioavailability of tacrolimus varies greatly between individuals and depends largely on the activity of both the cytochrome P450 3A (CYP3A) subfamily and P-glycoprotein (P-gp). The possible influence of single nucleotide polymorphisms (SNPs) of CYP3A subfamily and P-gp (MDR-1) in liver transplant recipients has recently been indicated as one of the most important variables affecting the… CONTINUE READING

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The concentration / dose ratio of recipients with CYP3A5 1 homozygotes was lowest compared to recipients with CYP3A5 3/ 3 and CYP3A5 1/ 3 genotypes .
The concentration / dose ratio of recipients with CYP3A5 1 homozygotes was lowest compared to recipients with CYP3A5 3/ 3 and CYP3A5 1/ 3 genotypes .
The possible influence of single nucleotide polymorphisms ( SNPs ) of CYP3A subfamily and P - gp ( MDR-1 ) in liver transplant recipients has recently been indicated as one of the most important variables affecting the pharmacokinetics of tacrolimus and the renal injury induced by tacrolimus .
The possible influence of single nucleotide polymorphisms ( SNPs ) of CYP3A subfamily and P - gp ( MDR-1 ) in liver transplant recipients has recently been indicated as one of the most important variables affecting the pharmacokinetics of tacrolimus and the renal injury induced by tacrolimus .
The possible influence of single nucleotide polymorphisms ( SNPs ) of CYP3A subfamily and P - gp ( MDR-1 ) in liver transplant recipients has recently been indicated as one of the most important variables affecting the pharmacokinetics of tacrolimus and the renal injury induced by tacrolimus .
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