Influence of Antioxidants on Leptin Metabolism and its Role in the Pathogenesis of Obesity.

@article{Mangge2017InfluenceOA,
  title={Influence of Antioxidants on Leptin Metabolism and its Role in the Pathogenesis of Obesity.},
  author={Harald Mangge and Christian Ciardi and Kathrin Becker and Barbara Strasser and Dietmar Fuchs and Johanna M Gostner},
  journal={Advances in experimental medicine and biology},
  year={2017},
  volume={960},
  pages={
          399-413
        }
}
Obesity is associated with low-grade inflammation. Leptin, a hormone made by fat cells regulates appetite and hunger and thus food intake behavior. Interestingly, , food preservatives like sodium sulfite and sodium benzoate and also natural colorant and spice compounds such as curcumin were found to decrease the release of leptin in murine 3T3-L1 adipocytes, after co-incubation with LPS, which was added to mimic the pro-inflammatory status in obesity. Several of these compounds are well known… CONTINUE READING