Influence of Aggregation and Route of Injection on the Biodistribution of Mouse Serum Albumin

  title={Influence of Aggregation and Route of Injection on the Biodistribution of Mouse Serum Albumin},
  author={Grzegorz M. Kijanka and Malgorzata Prokopowicz and Huub Schellekens and Vera Brinks},
  booktitle={PloS one},
Protein aggregates are a major risk factor for immunogenicity. Until now most studies on aggregate-driven immunogenicity have focused on linking physicochemical features of the aggregates to the formation of anti-drug antibodies. Lacking is however, basic knowledge on the effect of aggregation on the biodistribution and clearance of therapeutic proteins in vivo. The aim of current study was to get insight into the effect of aggregation on biodistribution in mice using different routes of… CONTINUE READING

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