Influence of Acute Alcohol Poisoning on Nerve Cells

  • Colin Stewart
  • Published 2003 in The Journal of experimental medicine


IN 1895 Dehio * demonstrated changes in the ganglion cells of the cerebellum produced by acute alcohol poisoning. In his research eight rabbits, o£ which two were controls and one, being diseased, was useless, formed the first series for experiment. Alcohol was administered by the stomach and by subcutaneous injection, the latter method producing the greatest result in the shortest time. The usual dose was 7 to 10 cubic centimetrcs of ninety-six per cent alcohol, reduced with water to about forty per cent, followed, as consciousness returned, by a further dose of 5 cubic centimetres, until in all 20 or 25 cubic centimetres had been given. Death occurred in from one to thirty-four hours, according to the amount given, though the rabbit living thirty-four hours was allowed to recover during the night. Slides were prepared by •issl's methylene-blue method. The alcohol effect was not observed with any certainty in those animals which died in the earlier stages of intoxication, while the others showed the following definite changes in the appearance of Purkinje's cells: The cells showed, instead of the normal, fine-meshed, stained network, fine irregularly arranged granules of approximately uniform size, while the normally unstained substance had taken on a pale blue tone. This change affected sometimes the whole of the cell, sometimes a part only, while nucleus, nucleolus, and the granules of

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@article{Stewart2003InfluenceOA, title={Influence of Acute Alcohol Poisoning on Nerve Cells}, author={Colin Stewart}, journal={The Journal of Experimental Medicine}, year={2003}, volume={1}, pages={623 - 629} }