Influence of Accelerated Storage Conditions on the Stability of Vancomycin-Loaded Poly ( D , L-lactide-co-glycolide ) Microspheres

@inproceedings{Sayin2006InfluenceOA,
  title={Influence of Accelerated Storage Conditions on the Stability of Vancomycin-Loaded Poly ( D , L-lactide-co-glycolide ) Microspheres},
  author={Burcu Sayin and Sema ÇALIfi},
  year={2006}
}
Poly(lactide-co-glycolide) (PLGA) polymers are widely used synthetic biodegradable materials, especially for controlled delivery of drugs, but conditions affecting degradation mechanisms of these polymers have not been studied in detail in microsphere systems. In this study, the effect of temperature and humidity on the stability and physicochemical characteristics of vancomycinloaded PLGA (75:25) (MW 136,000) microspheres was investigated. The changes in the surface morphology, drug content… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 27 REFERENCES

Effect of isothermal annealing on the hydrolytic degradation rate of poly ( lactide - co - glycolide ) ( PLGA )

  • Loo SCJ, CP Ooi, Wee SHE, Boey YCF
  • Biomaterials
  • 2005

Microsphere preparation by solvent evaporation method

  • DL Wise
  • Handbook of Pharmaceutical Controlled Release…
  • 2000

Microsphere preparation by solvent evaporation method, Wise DL (eds.), Handbook of Pharmaceutical Controlled Release

  • AA H›ncal, S. Çal›fl
  • 2000

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