Influence of ABCB1 genetic variants in breast cancer treatment outcomes.

@article{Chaturvedi2013InfluenceOA,
  title={Influence of ABCB1 genetic variants in breast cancer treatment outcomes.},
  author={Pankaj Kumar Chaturvedi and Sonam Tulsyan and Gaurav Agarwal and Priti Lal and Shefali Agarwal and Rama Devi Mittal and Bharti Mittal},
  journal={Cancer epidemiology},
  year={2013},
  volume={37 5},
  pages={
          754-61
        }
}
BACKGROUND Transportation of anticancer drugs such as anthracyclines across the membrane is regulated by P-glycoprotein encoded by the human multidrug resistance gene 1 (ABCB1). Polymorphisms in the ABCB1 gene (1236C>T, 2677G>T/A, 3435C>T) have been found to be associated with intrinsic and acquired cross resistance to these anticancer drugs. Therefore, the aim of this study is to evaluate the influence of ABCB1 gene polymorphisms in breast cancer treatment outcomes in terms of response and… CONTINUE READING

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