Influence of 5α-dihydrotestosterone and 17β-estradiol on human Sertoli cells metabolism.

@article{Oliveira2011InfluenceO5,
  title={Influence of 5α-dihydrotestosterone and 17β-estradiol on human Sertoli cells metabolism.},
  author={Pedro F Oliveira and Marco G Alves and Lu{\'i}s Rato and Joaquina Silva and Ros{\'a}lia S{\'a} and Alberto Barros and M{\'a}rio Sousa and Rui de Albuquerque Carvalho and Jose Eduardo B Cavaco and S{\'i}lvia Socorro},
  journal={International journal of andrology},
  year={2011},
  volume={34 6 Pt 2},
  pages={e612-20}
}
Sertoli cells metabolize glucose, converting it to lactate that is used by developing germ cells for their energy metabolism. Androgens and oestrogens have metabolic roles that reach far beyond reproductive processes. So, the main purpose of this study was to examine the effect of sex steroid hormones on metabolite secretion/consumption in human Sertoli cells. Human Sertoli cell-enriched primary cultures were maintained in a defined medium for 50 h and glucose, pyruvate, lactate and alanine… CONTINUE READING

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