Influence of 5,10-methylenetetrahydrofolate reductase polymorphism on whole-blood folate concentrations measured by LC-MS/MS, microbiologic assay, and bio-rad radioassay.

@article{Fazili2008InfluenceO5,
  title={Influence of 5,10-methylenetetrahydrofolate reductase polymorphism on whole-blood folate concentrations measured by LC-MS/MS, microbiologic assay, and bio-rad radioassay.},
  author={Zia Fazili and Christine M. Pfeiffer and Mindy Zhang and Ram B Jain and Deborah A. Koontz},
  journal={Clinical chemistry},
  year={2008},
  volume={54 1},
  pages={197-201}
}
BACKGROUND The 5,10-methylenetetrahydrofolate reductase (NADPH) (MTHFR) C677T polymorphism may affect whole-blood folate pattern measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and total folate measured by LC-MS/MS, microbiologic assay, and Bio-Rad radioassay (BR). METHODS We analyzed 171 whole blood hemolysates from 2 blood banks for folate pattern and total folate concentrations using these 3 methods and determined MTHFR genotype. RESULTS The median (range) total… CONTINUE READING
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